Date of Award

Spring 2018

Document Type


Terms of Use

© 2018 Zechen Zhang. All rights reserved. This work is freely available courtesy of the author. It may only be used for non-commercial, educational, and research purposes. For all other uses, including reproduction and distribution, please contact the copyright holder.

Degree Name

Bachelor of Arts


Physics & Astronomy Department

First Advisor

Rob B. Phillips

Second Advisor

Catherine Hirshfeld Crouch


We propose a theory for temperature-sensitive transcription factors under the allostery framework. We show that the allostery theory due to excess vibrational entropy and conformational energy difference can produce a thermal switch behavior that is experimentally observed in the literature. The theory paves the way for a complete model of a tunable thermal bioswitch.

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Physics Commons