Date of Award
Spring 2018
Document Type
Thesis
Terms of Use
© 2018 Zechen Zhang. All rights reserved. This work is freely available courtesy of the author. It may only be used for non-commercial, educational, and research purposes. For all other uses, including reproduction and distribution, please contact the copyright holder.
Degree Name
Bachelor of Arts
Department
Physics & Astronomy Department
First Advisor
Rob B. Phillips
Second Advisor
Catherine Hirshfeld Crouch
Abstract
We propose a theory for temperature-sensitive transcription factors under the allostery framework. We show that the allostery theory due to excess vibrational entropy and conformational energy difference can produce a thermal switch behavior that is experimentally observed in the literature. The theory paves the way for a complete model of a tunable thermal bioswitch.
Recommended Citation
Zhang, Zechen , '18, "A Theory for Allosteric Temperature-Sensitive Transcription Factors" (2018). Senior Theses, Projects, and Awards. 697.
https://works.swarthmore.edu/theses/697