Behavioural Brain Research
The opiate-receptor antagonist naloxone was administered to rats after passive-avoidance training either alone or in combination with forced-swim stress. A retention test revealed that while naloxone enhanced retention when administered alone, it impaired retention when administered in combination with forced-swim stress. The findings provide evidence for a “protective” endogenous opioid-based system that, when not blocked pharmacologically, limits enhancement or impairment of retention under conditions of mild and intense stress, respectively.
Allen M. Schneider; Peter E. Simson , '78; Krista Joan Spiller , '06; Jonathan Seth Adelstein , '06; Amanda Alice Vacharat , '06; K. R. Short; and Lynn G. Kirby , '89.
"Stress-Dependent Enhancement And Impairment Of Retention By Naloxone: Evidence For An Endogenous Opioid-Based Modulatory System Protective Of Memory".
Behavioural Brain Research.