Stress-Dependent Enhancement And Impairment Of Retention By Naloxone: Evidence For An Endogenous Opioid-Based Modulatory System Protective Of Memory

Authors

Allen M. Schneider, Swarthmore CollegeFollow
Peter E. Simson , '78
Krista Joan Spiller , '06
Jonathan Seth Adelstein , '06
Amanda Alice Vacharat , '06
K. R. Short
Lynn G. Kirby , '89

Document Type

Article

Publication Date

12-1-2009

Published In

Behavioural Brain Research

Abstract

The opiate-receptor antagonist naloxone was administered to rats after passive-avoidance training either alone or in combination with forced-swim stress. A retention test revealed that while naloxone enhanced retention when administered alone, it impaired retention when administered in combination with forced-swim stress. The findings provide evidence for a “protective” endogenous opioid-based system that, when not blocked pharmacologically, limits enhancement or impairment of retention under conditions of mild and intense stress, respectively.

Comments

This work is a preprint that has been provided to PubMed Central courtesy of Elsevier.

This paper was originally presented at the 2009 Society for Neuroscience meeting.

Recommended Citation

Allen M. Schneider; Peter E. Simson , '78; Krista Joan Spiller , '06; Jonathan Seth Adelstein , '06; Amanda Alice Vacharat , '06; K. R. Short; and Lynn G. Kirby , '89. (2009). "Stress-Dependent Enhancement And Impairment Of Retention By Naloxone: Evidence For An Endogenous Opioid-Based Modulatory System Protective Of Memory". Behavioural Brain Research. Volume 205, Issue 1. 290-293. DOI: 10.1016/j.bbr.2009.06.007
https://works.swarthmore.edu/fac-psychology/99