Beta-Adrenergic Receptor Blockade By Propranolol Enhances Retention In A Multitrial Passive-Avoidance Procedure

Authors

Allen M. Schneider, Swarthmore CollegeFollow
Nancy Koven , '98
Kimberly A. Lombardo , '98
Dimitriy A. Levin , '01
Peter E. Simson , '78

Document Type

Article

Publication Date

12-1-2000

Published In

Journal Of Behavioral Neuroscience

Abstract

The effect of beta -adrenergic receptor blockade on retention in a mildly aversive passive-avoidance procedure was investigated. Rats were given passive-avoidance training-1 trial per day for 4 days-and were administered saline, the centrally and peripherally acting beta -adrenergic blocker propranolol (4 or 10 mg/kg ip), or the peripherally acting P-adrenergic blocker sotalol (4 or 10 mg/kg ip) immediately or 2 hr after the Ist trial. Enhanced retention occurred only with the higher dose (10 mg/kg) of propranolol and only when it was administered immediately after training. The enhanced retention produced by propranolol is discussed in terms of opposing, regionally specific actions of beta -adrenergic receptor-mediated neural circuits on modulation of memory.

Comments

This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.

Recommended Citation

Allen M. Schneider; Nancy Koven , '98; Kimberly A. Lombardo , '98; Dimitriy A. Levin , '01; and Peter E. Simson , '78. (2000). "Beta-Adrenergic Receptor Blockade By Propranolol Enhances Retention In A Multitrial Passive-Avoidance Procedure". Journal Of Behavioral Neuroscience. Volume 114, Issue 6. 1256-1260. DOI: 10.1037/0735-7044.114.6.1256
https://works.swarthmore.edu/fac-psychology/2