Treatment Of Acute Intravascular Thrombi With Diagnostic Ultrasound And Intravenous Microbubbles
JACC: Cardiovascular Imaging
The purpose of this study was to determine whether high mechanical index (MI) impulses from diagnostic ultrasound (DUS) could dissolve intravascular thrombi using intravenous microbubbles. Using a canine model, DUS was applied during a continuous intravenous infusion of microbubbles. Completely thrombosed grafts were assigned to 2 treatment regimens: low-MI (0.5 was applied. In grafts treated with intermittent high-MI ultrasound, angiographic success was 71% at 30 min and 79% at 45 min, compared with 20% and 30% at these times in the low-MI ultrasound alone group (p < 0.05). We conclude that a commercially available DUS transducer can successfully recanalize acute intravascular thrombi during a continuous microbubble infusion.
cavitation, microbubbles, ultrasound, thrombolysis
F. Xie, J. Lof, E. Carr Everbach, A. M. He, R. M. Bennett, T. Matsunaga, J. Johanning, and T. R. Porter.
"Treatment Of Acute Intravascular Thrombi With Diagnostic Ultrasound And Intravenous Microbubbles".
JACC: Cardiovascular Imaging.