OGA Inhibition By GlcNAc-Selenazoline

Authors

E. J. Kim
D. C. Love
E. Darout
M. Abdo
B. Rempel
S. G. Withers
Paul R. Rablen, Swarthmore CollegeFollow
J. A. Hanover
S. Knapp

Document Type

Article

Publication Date

10-1-2010

Published In

Bioorganic And Medicinal Chemistry

Abstract

The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes. (C) 2010 Elsevier Ltd. All rights reserved.

Comments

This work is a preprint that has been provided to PubMed Central courtesy of Elsevier.

Recommended Citation

E. J. Kim, D. C. Love, E. Darout, M. Abdo, B. Rempel, S. G. Withers, Paul R. Rablen, J. A. Hanover, and S. Knapp. (2010). "OGA Inhibition By GlcNAc-Selenazoline". Bioorganic And Medicinal Chemistry. Volume 18, Issue 19. 7058-7064. DOI: 10.1016/j.bmc.2010.08.010
https://works.swarthmore.edu/fac-chemistry/90