Linear Free Energy Relationships Implicate Three Modes Of Binding For Fluoroaromatic Inhibitors To A Mutant Of Carbonic Anhydrase II
Document Type
Article
Publication Date
5-4-2000
Published In
Organic Letters
Abstract
Linear free energy relationships between binding affinity and hydrophobicity for a library of fluoroaromatic inhibitors of F131V carbonic anhydrase II (CA) implicate three modes of interaction. X-ray crystal structures suggest that F131 interacts with fluoroaromatic inhibitors, while P202, on the opposite side of the active site cleft, serves as the site of the hydrophobic contact in the case of the F131V mutant. 2-Fluorinated compounds bind more tightly, perhaps due to the field effect of the nearby fluorine on the acidity of the amide proton.
Recommended Citation
Jeffrey B. Doyon , '00; Elizabeth A. M. Hansen , '02; C. Y. Kim; J. S. Chang; D. W. Christianson; Ryan D. Madder , '00; Judith G. Voet; T. A. Baird; C. A. Fierke; and A. Jain.
(2000).
"Linear Free Energy Relationships Implicate Three Modes Of Binding For Fluoroaromatic Inhibitors To A Mutant Of Carbonic Anhydrase II".
Organic Letters.
Volume 2,
Issue 9.
1189-1192.
DOI: 10.1021/ol005608r
https://works.swarthmore.edu/fac-chemistry/169