Document Type
Article
Publication Date
2024
Published In
Scientific Reports
Abstract
Deletions and malfunctions of the IgLON family of cell adhesion molecules are associated with anatomical, behavioral, and metabolic manifestations of neuropsychiatric disorders. We have previously shown that IgLON genes are expressed in sensory nuclei/pathways and that IgLON proteins modulate sensory processing. Here, we examined the expression of IgLON alternative promoter-specific isoforms during embryonic development and studied the sensory consequences of the anatomical changes when one of the IgLON genes, Negr1, is knocked out. At the embryonal age of E12.5 and E13.5, various IgLONs were distributed differentially and dynamically in the developing sensory areas within the central and peripheral nervous system, as well as in limbs and mammary glands. Sensory tests showed that Negr1 deficiency causes differences in vestibular function and temperature sensitivity in the knockout mice. Sex-specific differences were noted across olfaction, vestibular functioning, temperature regulation, and mechanical sensitivity. Our findings highlight the involvement of IgLON molecules during sensory circuit formation and suggest Negr1’s critical role in somatosensory processing.
Keywords
IgLON, NEGR1, LSAMP, PNS, DRG, Sensory processing
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
K. Singh, M. Jayaram, A. Hanumantharaju, T. Tõnissoo, T. Jagomäe, K. Mikheim, S. Muthuraman, Scott F. Gilbert, M. Plaas, M. K. E. Schäfer, J. Innos, K. Lilleväli, M.-A. Philips, and E. Vasar.
(2024).
"The IgLON Family Of Cell Adhesion Molecules Expressed In Developing Neural Circuits Ensure The Proper Functioning Of The Sensory System In Mice".
Scientific Reports.
Volume 14,
DOI: 10.1038/s41598-024-73358-z
https://works.swarthmore.edu/fac-biology/714
Comments
This work is freely available under a Creative Commons license.