Document Type
Book Chapter
Publication Date
2016
Published In
Epstein's Inborn Errors Of Development: The Molecular Basis Of Clinical Disorders On Morphogenesis
Abstract
Developmental biology is the science connecting genetics with anatomy, making sense out of both. The body builds itself from the instructions of the inherited DNA and the cytoplasmic system that interprets the DNA into genes and creates intracellular and cellular networks to generation the observable phenotype. Even ecological factors such as diet and stress may modify the DNA such that different phenotypes can be constructed from the same DNA. During the past two decades, the basic principles of development have become known; although this brief chapter cannot do them justice (see, for example, Gilbert, 2013), they cover the following: mechanisms of differential gene expression; combinatorial logic of enhancers and promoters; signal-transduction pathways linking cell membrane and nucleus; mechanisms by which syndromes occur; the repertoire of morphogenetic interactions and the molecules causing them; environmental agents of phenotype production.
Edition
3rd
Published By
Oxford University Press
Editor(s)
C. J. Epstein, R. P. Erickson, And A. Wynshaw-Boris
Recommended Citation
Scott F. Gilbert and R. Rice.
(2016). 3rd.
"Principles Of Differentiation And Morphogenesis".
Epstein's Inborn Errors Of Development: The Molecular Basis Of Clinical Disorders On Morphogenesis.
9-21.
https://works.swarthmore.edu/fac-biology/436
Comments
This material was originally published in Epstein's Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis, 3rd edition, edited by Robert P. Erickson and Anthony J. Wynshaw-Boris, and has been reproduced by permission of Oxford University Press. For permission to reuse this material, please visit http://global.oup.com/academic/rights.