A Neutralizing Monoclonal Antibody Against Poliovirus And Its Reaction With Related Antigens

Document Type

Article

Publication Date

11-1-1981

Published In

Virology

Abstract

A neutralizing monoclonal antibody against type 1 poliovirus reacted, not only with native virions (N-antigen) as expected, but also with naturally occurring RNA-free proteins shells (70 S) and with 14 S assembly subunits previously thought to lack N-antigenic sites. The latter finding has important implications for development of subunit vaccines for poliovirus and probably for other picornaviruses as well.

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