Title

Mitotic Membrane Turnover Coordinates Differential Induction Of The Heart Progenitor Lineage

Document Type

Article

Publication Date

9-14-2015

Published In

Developmental Cell

Abstract

In the ascidian Ciona intestinalis, nascent heart progenitor cells inherit an adherent membrane associated with elevated levels of FGFR signaling. Cota and Davidson now explain the basis for this observation, showing that adhesion, via effects on Caveolin-rich membrane domains, limits FGFR internalization, leading to receptor enrichment at the adherent membrane.