NAN-190 Potentiates The Impairment Of Retention Produced By Swim Stress
Pharmacology Biochemistry And Behavior
Exposing rats to stress in the form of forced swim immediately after passive-avoidance training impaired retention. In contrast, exposure to the same stressor 2 h after training failed to impair retention. Systemic administration of the 5-HT1A receptor antagonist NAN-190 (1 mg/kg) immediately after forced swim markedly potentiated the stress-induced impairment of retention. In contrast, NAN-190 failed to affect retention when administered 2 h after forced swim or in forced swim's absence. These findings provide evidence for a NAN-190-sensitive system modulating retention that is 1) activated during a critical period shortly after exposure to swim stress, and 2) protective of memory, thereby limiting the extent to which retention is impaired by experiential stress.
Allen M. Schneider and Peter E. Simson , '78.
"NAN-190 Potentiates The Impairment Of Retention Produced By Swim Stress".
Pharmacology Biochemistry And Behavior.