Interactions Of Porphyrins With Nucleotides And Nucleic Acids

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Journal Of Molecular Catalysis


A number of features of porphyrin and metalloporphyrin interactions with nucleic acids are discussed. The role of base pair opening in porphyrin intercalation, the influence of ionic strength on base specificity and the basis for zinc porphyrin/DNA relaxation effects are explored. In addition, preliminary results dealing with the interactions of porphyrins and metalloporphyrins with mononucleotides are presented. For porphyrin derivatives having no axial ligands a stacking type interaction seems likely, but a second type of interaction, perhaps involving hydrogen bonding, may be important with iron(III) and cobalt(III) porphyrin derivatives.

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