A Brief History Of Premolecular Induction Studies

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Seminars In Cell & Developmental Biology


Induction was recognized by the embryological anatomists of the early nineteenth century, and it was seen to involve interactions between the component embryonic parts and between the embryo and its environment. In the 1920s, Spemann's laboratory redefined and reinvigorated the concept of induction, making it the center of embryology. This concept of induction incorporated both morphogenesis and differentiation. In the 1930s, studies of embryonic induction merged with those of gradients to form a world-wide research program that sought to find the molecular agents of these phenomena. Work in induction then continued on its own paths, but also stimulated the new field of developmental genetics.

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