Title

Retrograde Amnesic Effects Of Unilateral Speading Depression

Document Type

Article

Publication Date

7-1-1972

Published In

Physiology And Behavior

Abstract

Rats were trained with neither hemisphere depressed, were depressed in one hemisphere 3, 15, or 180 min after training and were tested with neither hemisphere depressed. Retention was impaired with the 3-min but not the 15 or 180-min interval. Other rats were trained with neither hemisphere depressed, were depressed in one hemisphere 3 min after training and were depressed in either the same or opposite hemisphere during testing. Impairment increased relative to retention tested under normal cortical conditions and was greater with depression in the opposite than in the same hemisphere. The data were taken to indicate that depression of a single hemisphere after training interfered with memory storage and depression during testing interfered with memory storage and stimulus control.

Keywords

Retrograde amnesia, Spreading depression, Memory consolidation, Stimulus control, Generalization decrement

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