Document Type
Conference Proceeding
Publication Date
5-1-2013
Published In
Proceedings Of Meetings On Acoustics
Abstract
Previous studies have shown that thrombi, which may completely block the blood flow in a vessel, can be dissolved by ultrasound acting on echo-contrast agent microbubbles. The presumed mechanism is acoustic cavitation, the radial oscillations of the bubbles, which can exert locally large forces on the fibrin ropes that make up the clot matrix. However, the movement of the bubbles through the clot in the absence of flow suggests that acoustic radiation force also plays an important role. Because detailed mechanistic modeling of this process is not available, we present here a heuristic study in which microbubble transit times in gels of various porosities were measured and described by a simplified percolation theory. Results suggest considerations for optimizing the penetration of active microbubbles in sonothrombolysis.
Keywords
Fluid bubbles, ultrasonics, acoustic cavitation, gels, percolation
Conference
21st International Congress On Acoustics
Conference Dates
June 2-7, 2013
Conference Location
Montréal, Canada
Recommended Citation
E. Carr Everbach and Ascanio Guarini , '16.
(2013).
"Modeling Of Microbubbles Pushed Through Clots Via Acoustic Radiation Force".
Proceedings Of Meetings On Acoustics.
Volume 19,
DOI: 10.1121/1.4800645
https://works.swarthmore.edu/fac-engineering/106