Title

Porphyrin Assembly Formation On Helical Biopolymers

Document Type

Article

Publication Date

3-1-1993

Published In

Journal Of Inorganic And Organometallic Polymers

Abstract

Studies on the interactions oftrans-bis(N-methylpyridinium-4-yl)diphenylporphine with DNA and polyglutamate lead to a model for binding in which the porphyrin, under appropriate conditions of concentration and ionic strength, forms long-range assemblies on the polymer template. Large, conservative induced circular dichroism signals are observed in the Soret region as a result of the assembly process. The phasing of the signal is a consequence of the helical sense of the porphyrin stacking, which, in turn, reflects the helicity of the polymer. The assembly organization can be inhibited by modifying solution conditions either to make porphyrin aggregation less favorable or to convert the polymer to a nonhelical conformation.

Keywords

Self-assembly, porphyrins, aggregation, circular dichroism, nucleic acid, polypeptides

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