Title

Interaction With DNA Of The Novel Cationic Complex (2, 2′: 6′, 2″-Terpyridine)Methyl Platinum(II)

Document Type

Conference Proceeding

Publication Date

9-1-1994

Published In

Il Nuovo Cimento D

Abstract

The planarity and electron delocalization of the 2, 2′:6′, 2″-terpyridine (terpy) moiety in salts of the type [Pt(terpy)Me]X leads to extensive stacking interactions in aqueous solution. UV/VIS, 1H NMR and resonance light scattering spectra provide evidence for the tendency of the complex to form large aggregates even under low ionic strength conditions. The interaction of the cationic complex with calf thymus DNA was investigated by spectroscopic techniques and mobility assays. At high r f ratios the complex seems to form extended aggregates on the surface of the nucleic acid but at lower r f evidence was obtained for intercalation.

Keywords

Molecular biophysics

Conference

I International Conference on Scaling Concepts and Complex Fluids

Conference Dates

Juy 4-8, 1994

Conference Location

Copanello, Italy

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