A Neutralizing Monoclonal Antibody Against Poliovirus And Its Reaction With Related Antigens
A neutralizing monoclonal antibody against type 1 poliovirus reacted, not only with native virions (N-antigen) as expected, but also with naturally occurring RNA-free proteins shells (70 S) and with 14 S assembly subunits previously thought to lack N-antigenic sites. The latter finding has important implications for development of subunit vaccines for poliovirus and probably for other picornaviruses as well.
J. Icenogle, Scott F. Gilbert, J. Grieves, J. Anderegg, and R. Rueckert.
"A Neutralizing Monoclonal Antibody Against Poliovirus And Its Reaction With Related Antigens".
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